
Clostridioides difficile (C. diff) is a harmful bacterium that causes diarrhoea, stomach pain, nausea, and fever. It is responsible for half a million infections in the US annually, with many infections occurring in hospitals. C. diff spreads through person-to-person contact and contaminated surfaces. To prevent C. diff infections in hospitals, strict hygiene protocols must be followed, including handwashing with soap and water, daily showers, and disinfection of surfaces and laundry. Hospitals should implement contact precautions, such as gloves and gowns, and ensure the proper use of antibiotics to prevent the overgrowth of C. diff. Surveillance programs are also crucial for early detection and outbreak prevention within healthcare facilities.
How to prevent C. diff in hospitals
| Characteristics | Values |
|---|---|
| Hand hygiene | Wash hands with soap and water, especially after using the bathroom and before eating |
| Showers | Take daily showers with soap and water to reduce C. diff on the skin |
| Laundry | Wash linens and clothes with the highest temperature setting |
| Surface disinfection | Clean high-touch areas with hospital-grade cleaner and EPA-registered disinfectant |
| Antibiotics | Only take antibiotics when necessary and talk to a healthcare professional about the best treatment |
| Surveillance programs | Implement surveillance programs to detect and prevent outbreaks |
| Contact precautions | Place spatial separation between beds and extend contact precautions for residents who are incontinent |
| Gowns and gloves | Healthcare providers should wear gowns and gloves when treating patients with C. diff |
| Probiotics and yogurt | May be a low-risk way to introduce healthy bacteria into the gut |
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What You'll Learn

Wash hands with soap and water
Washing hands with soap and water is one of the most effective ways to prevent the spread of C. diff infection in hospitals. This simple act can significantly reduce the risk of transmission and protect both patients and healthcare workers. Here are some detailed instructions and guidelines to ensure proper hand hygiene:
Handwashing Technique:
- Wet your hands with clean, running water, preferably warm or cold. Avoid hot water as it can irritate the skin.
- Apply soap and lather well, covering all surfaces of your hands, including the backs of your hands, between your fingers, and under your nails.
- Rub your hands vigorously for at least 20 seconds. Ensure you create a rich lather.
- Pay close attention to your fingertips, thumbs, and areas that tend to be overlooked, such as the wrists.
- Rinse your hands thoroughly under clean, running water to remove all soap residue.
- Dry your hands completely using a clean towel, disposable paper towel, or air dryer.
When to Wash Your Hands:
- Wash your hands before and after any contact with a patient infected with C. diff. This includes before putting on gloves and after removing them.
- Always wash your hands after using the restroom and before eating. C. diff spores can be transmitted through contact with contaminated surfaces, so maintaining hand hygiene after touching door handles, bed rails, or other high-touch areas is crucial.
- If you are a patient with C. diff, wash your hands frequently, especially during and after an infection. This will help reduce the spread of spores to your surroundings.
- Remind visitors, friends, and family members providing care to also adhere to strict handwashing protocols.
Additional Considerations:
- Ensure that soap dispensers are regularly refilled and that sinks are well-maintained to facilitate proper handwashing.
- If soap and water are not readily available, use alcohol-based hand sanitizers with at least 60% alcohol content. However, it's important to note that hand sanitizers are not as effective as soap and water in removing C. diff spores.
- Avoid touching your face, especially your eyes, nose, and mouth, after coming into contact with any potentially contaminated surfaces or items.
- Maintain good hand hygiene even when not in direct patient care areas, as C. diff spores can spread beyond the immediate patient environment.
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Clean and disinfect surfaces
Cleaning and disinfecting surfaces is an important step in preventing the spread of C. diff in hospitals. C. diff bacteria can live on surfaces and spread to others who touch them. Therefore, it is crucial to regularly clean and disinfect frequently touched surfaces in hospitals. Here are some detailed instructions for cleaning and disinfecting surfaces to prevent C. diff:
- Identify high-touch areas: Focus on frequently touched surfaces such as doorknobs, light switches, call buttons, bed rails, tables, toilets, and sinks. These areas should be prioritised for regular cleaning and disinfection.
- Use appropriate disinfectants: Select hospital-grade cleaners and Environmental Protection Agency (EPA)-registered sporicidal disinfectants. Follow the instructions on the product labels for effective use.
- Daily cleaning and disinfection: Implement a daily cleaning routine for all high-touch areas. This consistent practice will help reduce the presence of C. diff bacteria on surfaces.
- Use bleach-containing products: Many standard cleaning products are ineffective against C. diff bacteria. Choose cleaning and disinfecting products that contain bleach, as it is proven to kill C. diff spores.
- Laundry and linens: Wash linens, towels, washcloths, and clothes that come into contact with infected individuals. Use the highest temperature setting suitable for the fabrics. Dry cleaning is an option for items that cannot be washed, but it is less effective at killing C. diff spores.
- Hand hygiene: Promote good hand hygiene among healthcare workers, patients, and visitors. Provide accessible handwashing stations with soap and water or alcohol-based hand sanitizers. Ensure everyone washes their hands before and after interacting with patients, after using the restroom, and before eating.
By following these instructions for cleaning and disinfecting surfaces, hospitals can significantly reduce the spread of C. diff and protect the health and safety of patients, staff, and visitors.
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Use antibiotics only when necessary
Antibiotics are a common treatment for Clostridioides difficile (C. diff) infections (CDI). However, it is important to remember that antibiotics can kill beneficial bacteria in the gut, which can lead to an overgrowth of C. diff bacteria. This is why it is crucial to only take antibiotics when necessary.
C. diff infections are often caused by prior antibiotic use, which can kill beneficial bacteria in the gut, allowing harmful C. diff bacteria to multiply and cause severe diarrhea and colitis (inflammation of the colon). Doctors may feel pressured to prescribe antibiotics, even for viral illnesses that do not respond to antibiotics. Therefore, patients should only take antibiotics when they are truly needed and prescribed by a healthcare professional.
In addition, patients should be mindful of good hand hygiene and avoid close contact with others during and after their treatment for CDI, as C. diff can spread through person-to-person contact or by touching contaminated surfaces and then touching the face. Healthcare providers treating patients with C. diff infections should wear gloves and gowns, practising good hand hygiene by washing their hands with soap and water or using an alcohol-based cleanser when leaving the patient's room.
Furthermore, it is recommended to wash linens, clothes, and other fabrics that come into contact with an infected person at the highest temperature setting the fabric can withstand. Cleaning surfaces with bleach is also important, as many household cleaning products do not effectively kill C. diff bacteria.
While there is ongoing debate about the effectiveness of probiotics and yogurt in preventing CDI, these can be considered as low-risk ways to introduce beneficial bacteria into the gut. It is always best to consult a healthcare professional to determine the most suitable treatment option for an individual's illness.
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Wear gloves and gowns
Wearing gloves and gowns is an essential measure to prevent the spread of C. diff in hospitals. C. diff, or Clostridioides difficile, is a harmful bacterium that can cause severe gastrointestinal problems, especially in the colon, leading to diarrhea, stomach pain, nausea, and fever. It is often spread through physical contact, such as shaking hands, or by touching contaminated surfaces and then touching one's face.
Healthcare providers must wear gloves and a gown when caring for patients with C. diff infections. Gloves act as a protective barrier, preventing direct contact with infected individuals or contaminated surfaces. The gown provides an additional layer of protection, covering the clothing and body, reducing the risk of transferring C. diff germs to other patients or surfaces.
When putting on gloves and gowns, hospital workers should ensure they are intact and properly fitted. Any tears or holes in the gloves or gowns can compromise their effectiveness. It is also crucial to avoid touching the outside of the gloves or gown while removing them, as they are likely contaminated. After removal, hand hygiene is of utmost importance. Hands should be washed thoroughly with soap and water or cleaned using an alcohol-based cleanser.
Visitors to patients with C. diff infections may also be required to wear gloves and gowns. This measure helps prevent the spread of C. diff within the hospital and protects visitors from potential exposure. It is important for visitors to receive instruction and supervision when donning and removing personal protective equipment (PPE) to ensure its effectiveness and their safety.
Wearing gloves and gowns is a critical component of infection control in hospitals. By adhering to these measures, healthcare providers and visitors can help prevent the spread of C. diff and protect both themselves and vulnerable patients.
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Monitor and evaluate antimicrobial use
Antimicrobial medicines, such as antibiotics, are a common treatment for Clostridioides (Clostridium) difficile (C. diff) infections. However, the overuse and misuse of antibiotics can lead to antimicrobial resistance and, in some cases, even cause C. diff infections. Therefore, it is crucial to monitor and evaluate the use of antimicrobials in hospitals to prevent the spread of C. diff effectively.
Healthcare facilities should implement surveillance programs to monitor antimicrobial use and C. diff infections. This includes tracking the number of C. diff cases, especially those that arise in hospitals, and evaluating the use of antimicrobials in treating these infections. By collecting and analyzing data on antimicrobial usage and infection rates, hospitals can identify areas where improvements can be made to optimize patient care and prevent the spread of C. diff.
Prescribers and facility leadership should receive feedback on antimicrobial use through regular reports generated by the surveillance program. These reports should detail the types and quantities of antimicrobials used, as well as the effectiveness of these treatments in resolving C. diff infections. By providing this information, prescribers can make more informed decisions about antimicrobial prescriptions, ensuring that they are necessary and appropriate for each patient's condition.
In addition to surveillance and feedback, hospitals should also establish antimicrobial stewardship programs. These programs should provide education and training to healthcare professionals on the proper use of antimicrobials, including antibiotics. This includes guidance on when to prescribe antimicrobials, the appropriate duration of treatment, and potential alternatives or adjunctive therapies to reduce reliance on antimicrobials. By empowering healthcare providers with knowledge and resources, hospitals can improve patient outcomes and reduce the risk of C. diff infections associated with antimicrobial use.
Furthermore, hospitals should also monitor patient compliance with antimicrobial regimens. This includes educating patients about the importance of completing the entire course of prescribed antimicrobials, even if their symptoms improve, to reduce the risk of antimicrobial resistance and C. diff infections. Hospitals can also encourage patients to practice good hand hygiene, especially after using the restroom and before eating, to prevent the spread of C. diff through skin contact. By involving patients in infection prevention practices, hospitals can further reduce the transmission of C. diff within their facilities.
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Frequently asked questions
Wash your hands with soap and water, especially after using the bathroom and before eating. Take daily showers with soap and water to reduce C. diff on your skin.
Hospitals should ensure that healthcare providers wear gloves and gowns when treating patients with C. diff. Hospital workers and visitors should also practice good hand hygiene by washing their hands with soap and water or using an alcohol-based cleanser after leaving the patient's room.
Hospitals should use hospital-grade cleaners and disinfectants that are effective against C. diff spores. High-touch areas such as door knobs, light switches, call buttons, and bed rails should be cleaned and disinfected daily.
Take antibiotics only when necessary as they can kill healthy bacteria and lead to C. diff overgrowth. Maintain good hand hygiene and avoid close contact with others if you have C. diff to prevent spreading the infection.
Wash all linens and clothes with disinfectant laundry detergent at the highest temperature setting safe for the fabric. Dry cleaning is an option for clothes that cannot be washed, but it may not be as effective at killing C. diff spores.









































