
The Hospital of the University of Pennsylvania (HUP) is world-renowned for its clinical and research excellence. It has a rich history of top-notch patient care that began over two centuries ago with the founding of the nation's first medical school, the University of Pennsylvania. Pennsylvania Hospital is affiliated with the University of Pennsylvania, with its pathology faculty members holding Penn appointments. However, it is administratively separate from the University of Pennsylvania. The University of Pennsylvania-Penn Presbyterian was ranked as the 15th best hospital in the United States in 2020.
| Characteristics | Values |
|---|---|
| Administrative independence | The University of Pennsylvania and Pennsylvania Hospital are administratively separate. |
| Pathology faculty appointments | All pathology faculty members at the Children's Hospital of Philadelphia (CHOP) hold appointments at the University of Pennsylvania. |
| Integration | CHOP's pathology department is highly integrated with the University of Pennsylvania, serving as its pediatric arm (HUP). |
| Initiatives | CHOP and the University of Pennsylvania collaborate on neonatal autopsies, joint fellowship programs, educational components, and research cores. |
| Pediatric pathology rotations | Residents of the University of Pennsylvania can undertake pediatric pathology rotations at CHOP. |
| Department of Pathology and Laboratory Medicine | The University of Pennsylvania has a Department of Pathology and Laboratory Medicine, encompassing hospitals and entities within the Penn Medicine network and affiliated facilities. |
| Provider employment | Providers at these hospitals are employed by or contracted with the Clinical Practices or Clinical Care Associates of the University of Pennsylvania Health System. |
| Affiliated hospitals | Hospitals affiliated with the University of Pennsylvania include CHOP, Penn Presbyterian Medical Center, and Pennsylvania Hospital. |
| University rankings | In 2020, the University of Pennsylvania-Penn Presbyterian was ranked 15th best hospital in the US. |
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What You'll Learn

The Hospital of the University of Pennsylvania (HUP)
HUP is located at 3400 Spruce St, Philadelphia, PA 19104. The department chair is David B. Roth, MD, PhD, Simon Flexner Professor. HUP has a highly integrated relationship with the Children's Hospital of Philadelphia (CHOP). While CHOP is administratively separate, its pathology department functions as the pediatric arm of HUP. This integration includes performing all neonatal autopsies for HUP, running joint fellowship programs, and providing complementary educational and research components. As a result, CHOP's pathology department has become the largest pediatric pathology department in the nation.
HUP is part of the University of Pennsylvania Health System (UPHS), which includes other hospitals such as Penn Medicine Rittenhouse, Penn Medicine Cherry Hill (a facility of Penn Presbyterian Medical Center), and previously Phoenixville Hospital until its sale in 2004. In 2020, University of Pennsylvania-Penn Presbyterian was ranked as the 15th best hospital in the United States.
The University of Pennsylvania's Perelman School of Medicine is also closely associated with HUP and other hospitals in the UPHS network. Faculty members at these hospitals often hold appointments at the university, contributing to the integration of medical education, research, and patient care.
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Pathology department integration
The University of Pennsylvania (UPenn) and Pennsylvania Hospital are closely affiliated but are administratively separate. The Hospital of the University of Pennsylvania (HUP) is a teaching hospital for the University of Pennsylvania's School of Medicine. The Department of Pathology and Laboratory Medicine at UPenn encompasses a range of operations in hospitals and entities that are part of Penn Medicine or facilities affiliated with Penn Medicine hospitals.
The Pathology department at UPenn is highly integrated with the Children's Hospital of Philadelphia (CHOP). While CHOP is administratively separate from UPenn, all pathology faculty members at CHOP hold appointments at UPenn. This integration has resulted in several common initiatives, including performing all neonatal autopsies for HUP, running joint fellowship programs, and providing complementary educational and research components.
The Pathology department at UPenn is also affiliated with other hospitals and private practices. These include the Penn Presbyterian Medical Center, Chester County Hospital, Lancaster General Health, Penn Medicine Rittenhouse, and Penn Medicine Cherry Hill, among others.
Integration of the Pathology department across these hospitals and entities involves various aspects. Here are some key areas of integration:
- Clinical Practice: Integration ensures a unified approach to patient care, with consistent standards and practices across different hospitals and entities. This includes the utilization of digital pathology, which provides faster access to patient records, enables remote work and telepathology, and facilitates sharing of information for consultations and educational purposes.
- Research: Integration fosters collaboration in research endeavors, allowing for the pooling of resources, expertise, and patient data to advance pathological understanding and develop novel technologies. This includes the use of artificial intelligence (AI) to enhance diagnostic accuracy, productivity, and research capabilities.
- Education: Integrated pathology departments offer educational programs, fellowships, and rotations for residents and trainees. This integration ensures a consistent standard of medical education and facilitates the sharing of didactic slides and other educational resources.
- Administrative Services: Integration helps streamline administrative processes, reducing redundancy and improving efficiency. This includes the utilization of digital workflows, which provide faster access to information and reduce the need for manual administrative requests.
Overall, the integration of the Pathology department across UPenn and its affiliated hospitals aims to deliver high-quality patient care, advance research initiatives, provide comprehensive education, and improve administrative efficiencies. This integration allows for a cohesive and collaborative approach to pathology, benefiting patients, healthcare professionals, and the broader medical community.
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Providers at UPenn hospitals
The University of Pennsylvania (UPenn) is administratively separate from the Children's Hospital of Philadelphia (CHOP). However, all pathology faculty members at CHOP hold Penn appointments, resulting in the integration of its pathology department with Penn. The Hospital of the University of Pennsylvania (HUP) is part of Penn Medicine, and providers here are employed by or contracted with the Clinical Practices of the University of Pennsylvania or the Clinical Care Associates of the University of Pennsylvania Health System.
- David B. Roth, MD, PhD, Simon Flexner Professor and Chair, Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania.
- Anna M. Moran, MD, Interim Chair, Pathology and Laboratory Medicine at Penn Presbyterian Medical Center.
- John S. J. Brooks, MD, Emeritus Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania.
- Michael A. Husson, MD, Professor of Clinical Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania.
- Darshana N. Jhala, MD, MBBS, Professor of Clinical Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania.
Other UPenn-affiliated hospitals and practice locations include:
- Pennsylvania Hospital
- Penn Medicine University City
- Chester County Hospital Department of Pathology and Laboratory Medicine
- Lancaster General Health
- Penn Medicine Rittenhouse
- Penn Medicine Cherry Hill
- Penn Medicine Woodbury Heights
- Penn Medicine Princeton Health Laboratory Services
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UPenn's Perelman School of Medicine
The University of Pennsylvania (UPenn) and Pennsylvania Hospital are closely affiliated. The Hospital of the University of Pennsylvania (HUP) is the flagship teaching hospital of UPenn's Perelman School of Medicine.
The Perelman School of Medicine, commonly known as Penn Med, is the oldest medical school in the United States, founded in 1765. It is the medical school of UPenn, a private Ivy League research university located in Philadelphia. The Perelman School of Medicine is a major centre of biomedical research and education, with nearly 3,000 faculty members and over 2,500 students and trainees. The school consistently ranks among the top research-oriented medical schools in the country.
The Perelman School of Medicine has 28 basic and clinical departments, including basic science subjects such as biochemistry, biostatistics, cancer biology, genetics, neuroscience, and pharmacology, as well as clinical practices such as anaesthesiology, dermatology, emergency medicine, neurology, obstetrics and gynaecology, ophthalmology, orthopaedic surgery, pathology, pediatrics, psychiatry, and surgery.
The school's research enterprise covers all areas of contemporary biomedical investigation and is unified on a single campus. The school emphasises academic excellence and skillful compassion, with a focus on advancing knowledge and improving health through research, patient care, and education. The IMPaCT curriculum, instituted in 2022, emphasises small-group instruction, self-directed learning, and flexibility.
The Perelman School of Medicine and the University of Pennsylvania Health System (UPHS) comprise "Penn Medicine", an organisational structure that integrates Penn's clinical, educational, and research functions. Penn Medicine includes the Hospital of the University of Pennsylvania and other affiliated hospitals and practice locations, such as the Penn Presbyterian Medical Center, Pennsylvania Hospital, and the Children's Hospital of Philadelphia.
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UPHS network
The University of Pennsylvania Health System (UPHS) is a network of hospitals and health services with strong affiliations to the University of Pennsylvania (UPenn). The Hospital of the University of Pennsylvania (HUP) is the flagship hospital of the UPHS network and is closely integrated with the university, particularly through its Pathology department.
The UPHS network encompasses a range of hospitals and medical practices, including the Pennsylvania Hospital, Penn Presbyterian Medical Center, and the Children's Hospital of Philadelphia (CHOP). The network also includes private practices and physicians with privileges to treat patients at UPHS hospitals. Additionally, UPHS is affiliated with Penn Medicine, which operates various facilities, such as Penn Medicine Rittenhouse, Penn Medicine Cherry Hill, and Penn Medicine Princeton Health Laboratory Services.
The UPHS network provides comprehensive healthcare services to the community, ensuring access to advanced medical treatments and technologies. The network's hospitals offer a wide range of specialties, including pathology, laboratory medicine, pediatrics, and more. UPHS also prioritizes research and education, often collaborating with UPenn on joint initiatives, fellowship programs, and research endeavours.
In terms of technology and infrastructure, UPHS utilizes HUPNet (UPHSnet), a secure internal network similar to PSOMNet. This network manages all technological resources and activities across the health system's facilities. Within UPHS facilities, the physical network infrastructure and ports are managed by the UPHS Information Systems (UPHS IS) team. They work closely with Penn Medicine Academic Computing Services (PMACS) to determine the network access needs of end users and enable the necessary connections.
The UPHS network plays a vital role in delivering healthcare services, facilitating collaboration between healthcare professionals, and advancing medical research and education in partnership with UPenn. Together, the UPHS network and UPenn strive to provide the highest quality of care and innovation in the field of medicine.
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Frequently asked questions
No, they are administratively separate. However, all pathology faculty members at the Children's Hospital of Philadelphia (CHOP) have Penn appointments, and the Hospital of the University of Pennsylvania (HUP) is part of the University of Pennsylvania Health System.
The Hospital of the University of Pennsylvania (HUP) is part of the University of Pennsylvania Health System, and the Pathology Department at CHOP functions as the pediatric arm of HUP.
Yes, the University of Pennsylvania Health System includes several other hospitals, such as Penn Presbyterian Medical Center, Chester County Hospital, and Lancaster General Health. Phoenixville Hospital was also previously part of the network but has since been sold.










































