Tessa Quinn
The United States is home to several leading cancer hospitals and centres that have been recognised for their excellence in patient care, research, and innovation. Various institutions, including US News & World Report, Newsweek, and Statista, have ranked cancer hospitals in the US based on criteria such as patient experience, staffing, patient outcomes, infection prevention, timely and effective care, and cancer outcomes. While rankings may vary, some hospitals consistently appear in the top spots. So, what is America's leading cancer hospital, and how are these rankings determined?
| Characteristics | Values |
|---|---|
| Leading Cancer Hospital in America | University of Texas MD Anderson Cancer Center, Houston, TX |
| Memorial Sloan Kettering Cancer Center, New York, NY | |
| Ranking Factors | Patient experience, staffing, patient outcomes, safety, patient survival, and reputation among board-certified physicians |
| Data on infection prevention, timely and effective care, cancer outcomes, breast cancer screening, and patient satisfaction | |
| Vaccination rates of staff for Influenza and COVID-19 | |
| Accreditation from the Foundation for the Accreditation of Cellular Therapy (FACT) | |
| Other Leading Cancer Hospitals | Mayo Clinic, Rochester, Minnesota |
| Dana-Farber Brigham Cancer Center, Boston, MA | |
| Massachusetts General Hospital, Boston, MA | |
| Mount Sinai Hospital, New York, NY | |
| Stanford Health Care-Stanford Hospital, Palo Alto, CA | |
| City of Hope Comprehensive Cancer Center, Duarte, CA | |
| Johns Hopkins Hospital, Baltimore, Maryland | |
| Hospitals of the University of Pennsylvania-Penn Presbyterian Medical Center, Philadelphia |
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What You'll Learn
University of Texas MD Anderson Cancer Center, Houston
The University of Texas MD Anderson Cancer Center in Houston is one of the leading cancer hospitals in the US. It is the largest cancer center in the world and is both a degree-granting academic institution and a cancer treatment and research center. The center has consistently ranked among the best hospitals for cancer care and research in the US and worldwide. It has been ranked first for cancer treatment and research by US News and World Report, and in 2025, it was ranked the number one cancer hospital in the US by Newsweek.
The University of Texas MD Anderson Cancer Center has been at the forefront of cancer research and treatment for decades. It has been recognized for its groundbreaking research and innovative clinical care, providing new therapies years before they become standard in the community. The center is also known for its focus on patient-centric care and has received accolades for nursing excellence.
The center offers a wide range of cancer treatment and specialty services, including breast cancer, colorectal cancer, dermatology and skin cancer, endocrine cancer, genitourinary cancer, gynecologic cancer, head and neck cancer, neurologic cancer, and thoracic cancer. It operates several locations within the Greater Houston area, including MD Anderson League City and MD Anderson Sugar Land, allowing for better access to care for patients across the region.
The University of Texas MD Anderson Cancer Center also has a global presence, with sister institution relationships in Asia, Europe, Central America, and South America. In 2000, the center established its first global branch in Madrid, Spain, which has become a Center of Excellence for cancer treatment in Spain and Europe. Additionally, the center has a significant partnership with the Tata Memorial Hospital in Mumbai, India, focusing on enhancing cancer research, education, and clinical care.
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Memorial Sloan Kettering Cancer Center, New York
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan, New York City. It is one of 72 National Cancer Institute-designated Comprehensive Cancer Centers and is ranked second in the US for cancer care. The center was formed in 1980 from the merger of the Memorial Hospital for the Treatment of Cancer and Allied Diseases, founded in 1884, and the adjacent Sloan-Kettering Institute for Cancer Research, founded in 1945. The two institutions had been coordinating their operations since 1960.
The Memorial Hospital was founded in 1884 as the New York Cancer Hospital by a group that included John Jacob Astor III and his wife, Charlotte. In 1934, John D. Rockefeller Jr. donated land on York Avenue for the hospital's new location and granted the hospital $3 million (equivalent to $68 million in 2024) to fund the move. The Memorial Hospital officially reopened at its new location in 1939. In 1945, the chairman of General Motors, Alfred P. Sloan, donated $4 million (equivalent to $69.9 million in 2024) to create the Sloan-Kettering Institute for Cancer Research, which was built adjacent to Memorial Hospital.
The Memorial Sloan Kettering Cancer Center has been at the forefront of cancer research and treatment. From the mid-1950s to the mid-1960s, Chester M. Southam conducted pioneering clinical research on virotherapy and cancer immunotherapy at MSK, though his research was conducted without the patients' informed consent. In 1963, some doctors objected to the lack of consent and reported him to the Regents of the University of the State of New York. Southam was found guilty of fraud, deceit, and unprofessional conduct. MSK was one of the first cancer centers to receive the Comprehensive Cancer Center designation from the NCI in 1971. The center's doctors work closely with scientists to fulfill the institution's commitment to patient care, research, and education. MSK's experts have established standards of care and treatment protocols for each type and stage of cancer, offering a full range of programs to support patients and their families throughout all phases of treatment.
The center's main campus is located at 1275 York Avenue between 67th and 68th Streets in Manhattan, with other locations in New York City, Long Island, Westchester, and New Jersey. The New York Proton Center, a partnership between Memorial Sloan Kettering, Montefiore Health, and Mount Sinai Health System, opened in 2019 as the first proton therapy center in New York state. The David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center opened in January 2020, and the center launched its India facility in Chennai in August 2022, providing telemedicine services.
Memorial Sloan Kettering Cancer Center has received numerous accolades and rankings. It has been ranked second in the US for cancer care and first in the Northeast by US News & World Report. Newsweek ranked the center second in the world for oncology in 2025, and it was also ranked among the top 10 smart hospitals in the world in 2025. MSK's physicians have also been recognised, with two MSK physician-scientists, Andrea Cercek and Vinod Balachandran, named to the 2025 TIME100 Health list of the 100 most influential individuals in health.
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Mayo Clinic, Rochester
Mayo Clinic-Rochester in Rochester, Minnesota, is one of America's leading cancer hospitals. It is the original and largest Mayo Clinic campus, located in the heart of Rochester, Minnesota, a dynamic city just 90 minutes south of the Twin Cities of Minneapolis and St. Paul. Mayo Clinic has been safely treating patients from around the world for over 100 years.
Mayo Clinic-Rochester is nationally ranked in 13 adult specialties and 10 pediatric specialties. It is the only other US cancer centre apart from the University of Texas MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center to break into the top 10 of Newsweek's World's Best Specialized Hospital 2025 list for oncology. Mayo Clinic itself was ranked the No. 1 hospital in the world by Newsweek in 2025. Mayo Clinic has also been ranked number one in the United States for seven consecutive years in US News & World Report's Best Hospitals Honor Roll.
The hospital was founded by William Worrall Mayo, who settled in Rochester in 1864 and opened a sole proprietorship medical practice. This evolved under his sons, Will and Charlie Mayo, into the Mayo Clinic. Mayo Clinic-Rochester employs over 7,300 physicians and scientists, along with another 66,000 administrative and allied health staff. It is home to the top-15 ranked Mayo Clinic Alix School of Medicine and many of the highest-regarded residency education programs in the United States. The hospital spends over $660 million a year on research and has more than 3,000 full-time research personnel.
Mayo Clinic-Rochester offers a variety of wellness services, including spa services and healthy living classes, to help make patients' stays comfortable and enjoyable. It also performs near the highest number of transplants in the country, including both solid organ and hematologic transplantation.
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Dana-Farber Brigham Cancer Center, Boston
Dana-Farber Brigham Cancer Center in Boston, Massachusetts, is a world-renowned cancer treatment and research centre. It has been recognised as New England's top-ranked cancer centre for over 20 years and is nationally ranked in one adult specialty and one pediatric specialty.
The centre is known for its personalised approach to treatment and care, tailoring its services to each patient's unique needs and circumstances. Dana-Farber Brigham brings together advanced specialists from two leading medical centres, offering comprehensive and innovative treatments at the forefront of cancer research. Their multidisciplinary team includes doctors, nurses, and care staff who work together to provide confidence and support to patients and their families.
The centre treats a wide range of cancers, including breast cancer, as well as providing pioneering clinical trials and initiatives. For instance, in 2025, the centre collaborated with Boston Children's Hospital and Broad Clinical Labs to launch a precision genomics initiative for paediatric cancer. This commitment to innovation and collaboration ensures that patients have access to the latest advancements in cancer treatment.
The Dana-Farber Brigham Cancer Center is highly regarded for its expertise, compassion, and dedication to helping patients recover and improve their quality of life. Its reputation has attracted patients seeking the best cancer care available, with some patients specifically choosing this centre for its world-class specialists and compassionate care.
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City of Hope Comprehensive Cancer Center, Duarte, California
The City of Hope Comprehensive Cancer Center in Duarte, California, is one of the nation's top hospitals for cancer care. With a rich history spanning over 100 years, the centre has been consistently ranked among the best cancer hospitals in the country.
City of Hope is a National Cancer Institute (NCI)-designated comprehensive cancer centre, one of only 57 in the United States. This prestigious designation recognises the centre's excellence in treatment, research, and expertise in addressing the multifaceted nature of cancer. The NCI designation also acknowledges City of Hope as a leader in cancer care, committed to translating research into innovative treatments for patients across the globe.
The Duarte campus, nestled in over 100 acres of lush landscapes, is a hub of innovation and compassion. It is home to a dedicated team of 1,000 scientists, 500 physicians, and 10,000 employees, all working collaboratively to bridge cutting-edge science with empathetic patient care. The centre's unique approach to care is renowned, attracting patients from across the United States seeking the latest treatment innovations.
City of Hope's doctors, clinicians, and scientists are pioneers in cancer prevention, research, and treatment. They have developed numerous breakthroughs in cancer treatment, ensuring that patients receive the best care with speed and efficiency. The centre takes a supportive care approach, combining state-of-the-art therapies with a focus on maintaining patients' quality of life. This comprehensive and personalised care is delivered by experts driving evolving technology and collaborating under one roof.
The centre provides a range of services, including treatment, screenings, and consultations. It also offers a shuttle service for patients and visitors, making it convenient to navigate the expansive campus and access key buildings. City of Hope has earned recognition as a founding member of the National Comprehensive Cancer Network, and its Magnet status from the American Nurses Credentialing Center (ANCC) further underscores its excellence in nursing practice and adherence to national standards.
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Frequently asked questions
The University of Texas MD Anderson Cancer Center in Houston, Texas, ranked first in the 2025 US News & World Report.
Memorial Sloan Kettering Cancer Center in New York, New York, ranked second in the 2025 US News & World Report. Other highly ranked cancer hospitals in the US include Mayo Clinic in Rochester, Minnesota, Dana-Farber Brigham Cancer Center in Boston, Massachusetts, and City of Hope Comprehensive Cancer Center in Duarte, California.
Rankings are based on a range of factors, including patient survival rates, safety, staffing levels, patient satisfaction, and the hospital's reputation among board-certified physicians.
