
Isolation and quarantine are two different things. Isolation is for people who have COVID-19, while quarantine is for those who may have been exposed but have not tested positive. The CDC recommends that those who have tested positive for COVID-19 should isolate for at least 10 days after symptoms first appear and only after their fever has subsided for at least 24 hours without medication. If you have been hospitalized or have a weak immune system, your doctor might recommend that you isolate for up to 20 days.
| Characteristics | Values |
|---|---|
| Who should isolate? | People who have COVID-19 |
| Who should quarantine? | People who may have had close contact with someone who has COVID-19 |
| How long should you isolate for? | For at least 10 days after symptoms first appear, and only after 24 hours without a fever. The CDC recommends staying in isolation until other symptoms begin to show signs of improvement. |
| When to stop isolation | When you have had two negative tests in a row at least 24 hours apart |
| How long should you quarantine for? | For 14 days from the last date of close contact with someone who has COVID-19 |
| What to do if you live with someone who has COVID-19 | Quarantine while they are sick and for 14 days after they end isolation |
| What to do if you have been hospitalised or have a weak immune system | Your healthcare provider may recommend that you stay in isolation for up to 20 days |
| What to do if you have new symptoms after you recover | It could be a new infection, and you may need to start isolation again |
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What You'll Learn

Isolation is recommended for those with COVID-19 symptoms
Isolation is an effective way to curb the spread of COVID-19 and protect vulnerable groups from severe illness. It is recommended that those with COVID-19 symptoms isolate and avoid contact with others. This includes staying at home or in the place where you were instructed to isolate.
If you are experiencing COVID-19 symptoms, it is important to monitor your health closely. Symptoms such as a cough and shortness of breath should be improving, and at least 10 days should have passed since the onset of your illness. Additionally, you should be free of fever for at least 24 hours without the use of fever-reducing medication.
It is also recommended to wear a face mask when leaving your home for any reason during the isolation period. If you live with others, it is crucial to maintain distance and avoid sharing personal items like dishes, towels, and bedding. If possible, use a separate bathroom and limit your contact with them, especially if they are at high risk for severe illness.
The duration of isolation may vary depending on individual circumstances. For those who are seriously ill or hospitalized with COVID-19, or have a weakened immune system, practitioners may advise an isolation period of up to 20 days. In some cases, isolation may end when an individual has had two consecutive negative tests at least 24 hours apart.
It is always best to follow the advice of your healthcare provider regarding isolation and quarantine periods, as guidelines may be subject to change.
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Isolation duration depends on symptoms and vaccination status
The duration of isolation depends on an individual's symptoms and vaccination status. The CDC recommends that people who have tested positive for COVID-19 isolate for at least 10 days after symptoms first appear and for 24 hours after a fever has subsided without medication. Additionally, individuals should continue to isolate until their symptoms show signs of improvement. However, it is important to note that the loss of taste and smell may persist for months and should not be considered a reason to extend isolation.
For those who are asymptomatic or have mild symptoms that do not require emergency medical care, the CDC recommends isolation for 5 days, regardless of vaccination status. After this period, individuals can leave isolation if they have no symptoms or their symptoms are improving, and they have been fever-free for at least 24 hours. However, it is advised to continue wearing a mask around others for at least five additional days.
In some cases, individuals may need to isolate for longer than 10 days. This includes those who were severely ill with COVID-19, required hospitalization, have a weak immune system, or continue to experience a fever or other symptoms. Healthcare providers may recommend isolation for up to 20 days for these individuals.
It is important to prioritize your health and the well-being of those around you. Isolation is a crucial step in preventing the spread of COVID-19 and protecting others from potential infection. By following the guidelines provided by the CDC and seeking advice from healthcare practitioners, individuals can make informed decisions about their isolation duration based on their specific circumstances.
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Seek medical advice on isolation after hospitalisation
The duration of isolation following hospitalisation varies depending on the illness and individual circumstances. For instance, the CDC recommends that people who have COVID-19 and can recover at home should isolate themselves. If you have tested positive for COVID-19 but are asymptomatic, the CDC advises you to isolate at home if possible, in a designated "sick room" with a separate bathroom.
The CDC recommends that people with COVID-19 isolate for at least 10 days after their symptoms first appear and for 24 hours after a fever has subsided without medication. It is also recommended to continue wearing a mask around others until at least the 10-day mark. Additionally, if you were seriously ill with COVID-19, had to be hospitalised, or have a weak immune system, your healthcare provider may advise you to isolate for up to 20 days.
It is important to note that you may need to isolate for longer than 10 days if you continue to have a fever or other symptoms. Your healthcare provider may recommend that you finish your isolation period at home. In some cases, you may be able to stop isolating when you have had two consecutive negative tests, at least 24 hours apart.
For other illnesses, such as the flu, RSV, or other respiratory illnesses, the CDC recommends following similar steps to COVID-19 isolation. It is advised to stay home and avoid contact with others until you are symptom-free for at least 24 hours without taking fever-reducing medications.
It is always best to consult your healthcare provider or practitioner for advice on how long to isolate after hospitalisation, as they can provide guidance based on your specific circumstances and the illness you are recovering from. They will take into account your risk factors and the risk of spreading the illness to others.
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Prevent COVID-19 spread with antiviral medication
While vaccination is the primary method of preventing the spread of COVID-19, antiviral medications can also be used to prevent severe illness and death. Antivirals treat viruses and prevent them from spreading by targeting specific parts of the virus to stop it from multiplying in the body once someone is infected. They work alongside your body's natural defenses to keep you safe from the invading virus.
The Infectious Diseases Society of America provides guidelines on the treatment and management of COVID-19 to help healthcare providers determine the best treatment options for their patients. Several treatment options are available, including Paxlovid, which may cause a metallic taste in your mouth as a side effect.
Uninfected people who began taking the antiviral drug ensitrelvir within 72 hours of symptoms first appearing in a household member were significantly less likely to contract COVID-19 than those given a placebo. This was demonstrated in the SCORPIO-PEP trial, a double-blind clinical trial conducted between June 2023 and September 2024. The trial showed that ensitrelvir could be an important addition to current preventive strategies.
It's important to note that antiviral treatments are not a replacement for COVID-19 vaccinations. Vaccines effectively protect people from getting seriously ill, being hospitalized, and even dying. However, people with weakened immune systems may require additional doses or antiviral treatments to prevent severe illness.
If you have COVID-19, it is essential to isolate yourself to prevent the spread of the virus to others. The CDC recommends that you isolate for at least 5 days if you test positive for COVID-19, regardless of vaccination status. You can leave isolation after 5 days if you have no symptoms or your symptoms are improving, including at least 24 hours without a fever. If you continue to have a fever or other symptoms, you may need to isolate for more than 5 days.
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Vaccination is the best defence against hospitalisation
Vaccination is indeed our best defence against hospitalisation. Vaccines are clinically proven to offer safe and effective protection against severe diseases and their variants, such as COVID-19, influenza, and pneumococcal disease, which includes pneumonia and meningitis.
The SARS-CoV-2 virus, which causes COVID-19, is constantly evolving, with new variants arising frequently. Vaccination remains the best defence against emerging variants of COVID-19. Those who are vaccinated are less likely to experience severe illness or hospitalisation due to COVID-19. According to the CDC, individuals with COVID-19 should isolate themselves for at least 5 days, regardless of their vaccination status.
Pneumococcal disease, caused by Streptococcus pneumoniae bacteria, is the second leading cause of death and a common reason for hospitalisation in Singapore. The pneumococcal vaccine provides strong protection against severe pneumococcal diseases, significantly reducing the chances of severe illness, hospitalisation, and even death.
In addition to COVID-19 and pneumococcal vaccines, seasonal influenza vaccines are also essential in protecting individuals and healthcare systems from the added pressures of winter viruses. Respiratory Syncytial Virus (RSV) is a common respiratory virus that can cause serious illness in infants and older adults. Vaccination against RSV is particularly crucial during the winter months when this virus typically spreads more easily.
By getting vaccinated, individuals can protect themselves, their loved ones, and their communities from severe illnesses that often lead to hospitalisation. Vaccination is a powerful tool that reduces the burden on healthcare services and saves lives.
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Frequently asked questions
The duration of your isolation depends on the severity of your illness and your vaccination status. If you were seriously ill with COVID-19 and required hospitalization, your healthcare provider may recommend that you stay in isolation for up to 20 days after your symptoms first appeared.
Yes, if you test positive for COVID-19, the CDC recommends that you isolate for at least 5 days, regardless of vaccination status. You can leave isolation after 5 days if you have no symptoms or your symptoms are improving, including at least 24 hours without a fever.
If you live with someone who is at high risk, such as older adults, pregnant women, or individuals with compromised immune systems, it is recommended that they stay elsewhere for 14 days if possible. If they cannot relocate, try to maintain distance and avoid close contact as much as possible during your isolation period.
It is generally recommended to avoid close contact with others until you are symptom-free for at least 24 hours without taking fever-reducing medications. Continue to wear a mask around others and follow the guidelines provided by your healthcare practitioner.





























