Tessa Quinn
Liver transplants are a crucial procedure for patients suffering from liver disease, offering them a second chance at life. While several hospitals across the United States perform liver transplants, some stand out for their high volume and innovative approaches. In 2024, the Cleveland Clinic Main Campus in Ohio led the way with 258 liver transplants. IU Health Methodist Hospital in Indiana and Piedmont Atlanta Hospital in Georgia also ranked high, performing 187 and 185 transplants, respectively. The University Health System Transplant Center in Texas is notable for its living liver donor program, and UCLA Health is recognized for its long-standing experience and research-driven advancements. UCSF Health, designated a center of excellence, has performed nearly 4,000 liver transplants since 1988. These hospitals are leaders in liver transplantation, offering hope and life-saving treatment to patients.
| Characteristics | Values |
|---|---|
| Top hospitals for liver transplants in the US | Cleveland Clinic Main Campus, IU Health Methodist Hospital, Piedmont Atlanta Hospital, University of Chicago Medical Center, UCLA Health, UCSF Health |
| Top hospitals for liver transplants worldwide | Bumrungrad International Hospital, Cedars-Sinai Medical Center, Nicklaus Children's Hospital, Dr. Sulaiman Al-Habib Hospital |
| Number of liver transplants performed in 2024 | Cleveland Clinic Main Campus: 258; IU Health Methodist Hospital: 187; Piedmont Atlanta Hospital: 185 |
| Liver transplant program features | Accommodation for out-of-town patients, mindfulness practices, support groups, living donor information, vaccination recommendations |
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What You'll Learn
Top hospitals for liver transplants
Liver transplantation is one of the best treatment options for patients suffering from liver disease and associated complications. The procedure involves removing the diseased liver and replacing it with a healthy one from a donor.
The Cleveland Clinic Main Campus in Cleveland, Ohio, is currently the leader in liver transplants in the United States. In 2024, they performed 258 liver transplants, the highest number in the country. The Cleveland Clinic is also one of the largest hospitals in the US in terms of bed count.
Following closely behind is the IU Health Methodist Hospital in Indianapolis, Indiana, which performed 187 liver transplants in 2024. This hospital is affiliated with Indiana University and is highly regarded as a leading academic medical centre.
The third-highest number of liver transplants in 2024 was performed at Piedmont Atlanta Hospital in Atlanta, Georgia. This facility has developed advanced technology to assist with organ transplants and is known for its expertise in this field.
Another top hospital for liver transplants is UCSF Health, which has a designated Liver Transplant Program. This programme has been designated a centre of excellence by the US Department of Health and Human Services. Since its founding in 1988, the programme has performed nearly 4,000 liver transplants, offering a second chance at life to patients with end-stage liver disease. UCSF Health also encourages patients awaiting liver transplants to get vaccinated and follow guidelines for immunocompromised individuals.
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Living donor liver transplants
Liver transplants are a life-saving procedure for patients with end-stage liver disease, offering them a second chance at life. While deceased donor livers are in short supply, living donor liver transplants are a viable option for patients awaiting liver transplants. This procedure involves removing a portion of the liver from a healthy adult donor and transplanting it into the recipient after removing their diseased liver. The liver's unique regenerative capacity allows the donor's and recipient's livers to regrow to their full size within a few weeks.
UT Southwestern Medical Center's Living-Donor Liver Transplant Program offers comprehensive and integrated care for patients, ensuring the safety, health, and interests of donors. Their skilled team includes surgeons, hepatologists, intensive care doctors, and other specialists. Similarly, Massachusetts General Hospital's Living Liver Donor program prioritises donor safety and provides the highest quality of care. Their evaluation and screening process ensures the wellbeing of donors and recipients, allowing donors to withdraw at any time.
UCSF Health is another leader in liver transplants, performing transplants using both deceased and living donors. Their program has helped nearly 4,000 patients since 1988 and is designated a centre of excellence by the U.S. Department of Health and Human Services. They have pioneered techniques to enhance transplantation safety and success, including creating new criteria for transplanting liver cancer patients, increasing patient eligibility.
The Cleveland Clinic Main Campus in Ohio performed the highest percentage of liver transplants in the U.S. in 2024, with 258 transplants. Other top hospitals include IU Health Methodist Hospital in Indiana and Piedmont Atlanta Hospital in Georgia, performing 187 and 185 transplants, respectively. These hospitals are renowned for their advanced technology and academic excellence in the field of organ transplants.
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Paired liver donation
Liver transplants are a treatment option for patients with liver disease or liver failure. The procedure involves removing the diseased liver and replacing it with a healthy liver from a donor. While liver transplants can extend a patient's life and improve their quality of life, there is a major organ shortage in the United States, limiting the number of transplants that can be performed.
One innovative method to increase the number of liver transplants is through paired liver donation, also known as a liver paired exchange program. This program allows for the expansion of the donor pool, especially for patients with ABO-incompatible and size-mismatched living donors. In a paired liver donation, two pairs of donors and recipients who are incompatible with their respective partners can swap donors, ensuring compatibility and allowing for successful transplants. This process requires four simultaneous operations: two living donor hepatectomies (donor-recipient operations) and two living donor liver transplants.
The success of kidney paired exchange programs in the United States has prompted liver transplant experts to explore similar programs. NewYork-Presbyterian, in collaboration with the United Network for Organ Sharing, is planning a Phase I pilot study to assess the safety and feasibility of a living donor liver paired exchange program. With enough experienced surgeons to perform paired exchanges, they aim to increase patients' options for donating or receiving a liver. To date, they have performed over 400 living donor liver transplants, the highest number in North America.
The Cleveland Clinic Main Campus in Cleveland, Ohio, is another leader in liver transplants, performing 258 transplants in 2024, the highest percentage in the United States that year. IU Health Methodist Hospital in Indianapolis, Indiana, and Piedmont Atlanta Hospital in Atlanta, Georgia, are also top hospitals for liver transplants, performing 187 and 185 transplants, respectively, in 2024. These hospitals play a crucial role in advancing organ transplantation and improving patients' lives.
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Pediatric liver transplants
Liver transplantation is one of the best treatment options for patients living with complications of liver disease. The procedure offers patients with end-stage liver disease a second chance at life. While organ transplantation can extend a patient’s life, improve their quality of life, and reduce the risk of chronic illness, the procedures are not without risks. Biopharma products like immunosuppressive drugs, monoclonal and polyclonal antibodies, and anti-infective prophylactics help prevent common complications including organ rejection and infection.
The Children's Hospital of Philadelphia (CHOP) is a world-renowned centre for paediatric liver transplants. Biliary atresia, a disease in which the bile ducts are obstructed, preventing bile from passing from the liver into the intestines, is the most common reason children need a liver transplant. CHOP is the leading centre for biliary atresia care and referrals and is part of the Biliary Atresia Research Consortium (BARC). The hospital also treats Alagille syndrome, a genetic disorder that often affects the liver, causing the bile ducts to narrow or fail.
Texas Children's Hospital also has an established liver transplant program, performing more than 35 paediatric liver transplants each year since 1988, for a total of more than 750 patients. The hospital is designated as a Wilson's Centre of Excellence and provides pre- and post-liver transplant care using advanced technology. Their dedicated pediatric liver transplant team includes a hepatologist, transplant infectious disease doctor, immunologist, neuropsychologist, transfusion medicine specialist, dietitian, pharmacist, child life specialist, and social worker.
UCSF Health is ranked among the nation's top 10 hospitals for liver transplants. Their Liver Transplant Program has helped nearly 4,000 patients since its founding in 1988 and has been designated a centre of excellence by the U.S. Department of Health and Human Services. UCSF performs transplants using both deceased and living donors and can perform complex transplants on patients with complicating health conditions such as portal vein thrombosis.
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Liver transplant patient care
Liver transplantation can be a life-saving procedure, offering patients with end-stage liver disease a second chance. While it can extend a patient's life and improve their quality of life, it is not without risks. Patients need to be educated about their medication and embrace a healthy lifestyle routine after the transplant.
Pre-Transplant Care
Before a liver transplant, patients undergo an evaluation to determine how advanced their liver disease is and whether their body is healthy enough to undergo the procedure. This includes testing and interviews with the transplant team, including coordinators, transplant assistants, a social worker, a pharmacist, therapists, hepatologists, surgeons, and doctors. Patients need support from family, friends, and caregivers during this evaluation phase and throughout the transplant process.
Transplant Surgery
The surgery itself can take up to 12 hours. If the patient receives a liver from a deceased donor, they get the entire liver. In living donor transplantation, most adults only need one liver lobe, which regenerates to its former size. Patients may remain in intensive care for several days after surgery, receiving nutrition through an IV line.
Post-Transplant Care
Post-transplant, patients need to take immunosuppressant medication to reduce the chance that their body will attack the donor liver. They also need to be aware of signs of infection and liver failure, and they will have frequent check-ups and blood tests to monitor their liver's health. Most people can return to work within three months and resume all activities within six to 12 months.
Leaders in Liver Transplantation
The Cleveland Clinic Main Campus in Ohio performed the highest percentage of liver transplants in the US in 2024, with 258 transplants. The IU Health Methodist Hospital in Indiana and Piedmont Atlanta Hospital in Georgia were also top-performing hospitals. UCSF Health in San Francisco is ranked among the top 10 hospitals for liver transplants and has performed nearly 4,000 transplants since 1988.
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Frequently asked questions
The following hospitals are considered leaders in liver transplants:
- Bumrungrad International Hospital in Bangkok
- Cleveland Clinic in Cleveland, Ohio
- Cedars-Sinai Medical Center
- Nicklaus Children's Hospital in Miami, Florida
- Dr. Sulaiman Al-Habib Hospital
- UCLA Health
- University Health System Transplant Center, in partnership with UT Health San Antonio
- UCSF Health
A hospital that performs a high volume of liver transplants with excellent outcomes can be considered a leader in liver transplants. Leaders in liver transplants also tend to have outstanding liver transplant programs, innovative research, and state-of-the-art technology.
The first step in getting a liver transplant is to find a hospital that offers liver transplants and determine if you are eligible. Once you are a candidate, you will be put on a waiting list as demand for liver transplants is very high. In the meantime, it is recommended that patients get vaccinated and follow guidelines for immunocompromised patients.
The success rate of liver transplants depends on the hospital and the patient's health condition. Generally, liver transplants are very successful, offering patients with end-stage liver disease a second chance at life. For example, the UCSF Liver Transplant Program has performed nearly 4,000 liver transplants since its founding in 1988 with outstanding outcomes.
