
North Carolina is home to several top-ranking hospitals, with some of the best medical facilities in the nation. With over 700 hospitals in the U.S. at risk of closure, it is important to identify the best hospitals in the state. UNC Rex Hospital is the only hospital in North Carolina to receive 22 consecutive A grades for patient quality and safety since 2012. Duke University Hospital in Durham is another top-ranking hospital, nationally ranked in 11 adult and nine pediatric specialties. Other notable mentions include Moses H. Cone Memorial Hospital, Novant Health Presbyterian Medical Center, and Atrium Health Carolinas Medical Center in Charlotte.
| Characteristics | Values |
|---|---|
| Best Hospitals in North Carolina | Atrium Health Carolinas Medical Center, UNC Rex Hospital, ECU Health Medical Center, FirstHealth Moore Regional Hospital, Mission Hospital-Asheville, Moses H. Cone Memorial Hospital, Novant Health Presbyterian Medical Center, Atrium Health-Cabarrus |
| Top-Ranked Hospital in North Carolina | Duke University Hospital, Durham |
| Largest Hospital in Wake County by Number of Beds | WakeMed Raleigh |
| Most Babies Delivered in Wake County | WakeMed Raleigh |
| Sole Hospital in North Carolina to Receive 22 Consecutive "A" Grades | UNC Rex |
| Top Honors in Business North Carolina's Annual Ranking | Moses Cone Hospital |
| Parent Company of Mission Hospital | HCA Healthcare |
| CEO of Mission Health and Mission Hospital | Greg Lowe |
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What You'll Learn

Duke University Hospital, Durham
Duke University Hospital, located in Durham, North Carolina, is a leading academic medical centre and the flagship teaching hospital for the Duke University Health System. With over 1000 beds, it is a full-service tertiary and quaternary care hospital, providing a comprehensive range of diagnostic, medical and surgical services. The hospital has a long history of innovation and excellence, dating back to its establishment in 1930. It was the first hospital to develop an outpatient bone marrow transplant program and perform lung and heart-lung transplants. Duke University Hospital was also a pioneer in cardiac surgery, being the first hospital to utilise systemic hypothermia to minimise tissue damage during lengthy surgeries. This technique has since become standard procedure in hospitals worldwide.
The hospital is part of the Duke University Medical Center, a group of patient care, education, and medical research facilities on the medical campus of Duke University. The medical centre offers equal access and free interpreter services for patients who prefer to communicate in a language other than English. It also provides free bus services to its campus for students, employees, patients, and visitors.
Duke University Hospital has consistently ranked among the nation's best hospitals by U.S. News & World Report and has achieved the nation's highest recognition for nursing excellence. It is one of the world's top academic health systems, alongside UNC Health, with which it is partnering to build a $2 billion freestanding children's health system in the Triangle.
The hospital's cancer centre, established in 1971, was officially designated as a "comprehensive" cancer centre by the National Cancer Institute in 1973. It was one of the first cancer centres in the nation under the National Cancer Act. The Duke Eye Centre, established in 1978, is another notable facility within the hospital.
Duke University Hospital has a rich history of advancements and firsts, including the establishment of the nation's first research centre for ageing, the Duke University Center for Aging, and the acceptance of the first African-American student into its medical school in 1963. The hospital also created the first physician assistant program in the country in 1965 and became the first medical centre to offer radio consultations with physicians in developing countries in 1966.
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UNC Rex, sole NC hospital with 22 straight 'A' grades
UNC Rex Hospital, part of UNC Health, is the only hospital in North Carolina to receive 22 consecutive "A" grades. This impressive feat has been achieved every year since 2012, when the Washington, D.C.-based Leapfrog Group began rating hospitals twice annually for patient quality and safety. UNC Rex is one of only 18 hospitals across the United States to attain this distinction.
In the Triangle, UNC Health and Duke Health, two of the world's foremost academic health systems, are collaborating on a $2 billion freestanding children's health facility. UNC Health received $320 million in funding from North Carolina lawmakers for this project, which is expected to break ground in 2027.
In 2023, UNC Rex Hospital generated $1.5 billion in net patient revenue, ranking it as the seventh-largest hospital in the state in terms of revenue. The hospital, which opened in 1964, serves a 20-county area and is led by Alisha Hutchens.
UNC Rex Hospital stands out among North Carolina's top hospitals, which include Atrium Health, Novant Health, ECU Health, and Duke University. Notably, Moses Cone Hospital was recognized as the best hospital in the state by Business North Carolina. Additionally, WakeMed Raleigh is Wake County's largest hospital in terms of bed numbers and is renowned for its maternity care, delivering nearly 10,000 babies during its 2024 fiscal year.
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Moses Cone Hospital, top honours in NC
Moses Cone Hospital has received top honours in North Carolina, but determining the best hospital in the state is a complex process that depends on a variety of factors.
Located at 1121 N. Church Street, Greensboro, NC, Moses Cone Hospital is highly regarded in the state. The hospital is ranked regionally by US News, which evaluates hospital performance in outcomes and access to care by socioeconomics and demographics. Moses Cone Hospital is also rated as "high performing" by US News, which means it ranks in the top 10% of all hospitals evaluated. The ratings are based on objective, publicly available data such as Medicare claims, and focus on patient outcomes, patient experience, care-related factors, and expert opinions.
Moses Cone Hospital is not the only hospital in North Carolina with top honours. UNC Rex Hospital is the sole hospital in the state to receive 22 consecutive "A" grades from the Washington, D.C.-based Leapfrog Group for patient quality and safety since 2012. Atrium Health Carolinas Medical Center in Charlotte is also nationally ranked in 1 adult specialty and 10 pediatric specialties. Additionally, WakeMed Raleigh is the largest hospital in Wake County by the number of beds and delivers more babies than any other health system in the county.
When determining the best hospital in North Carolina, it is important to consider various rankings and ratings, such as those provided by US News, Newsweek, and Statista, as well as patient satisfaction awards and Leapfrog Group ratings. These rankings take into account hospital quality metrics, patient experience surveys, safety, readmission rates, timely and effective care, and patient-reported outcomes.
In conclusion, while Moses Cone Hospital has received top honours in North Carolina, there are many other highly regarded hospitals in the state. The best hospital for an individual may depend on the type of care needed and other personal factors.
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Atrium Health, Charlotte, 1 adult and 10 pediatric specialties
Atrium Health, headquartered in Charlotte, North Carolina, is a leading healthcare provider in the region. With over 65,000 employees, including talented medical professionals and researchers, they are committed to delivering accessible and affordable healthcare to the community. Atrium Health's Carolinas Medical Center (CMC) stands out as one of its flagship hospitals, recognised for its comprehensive range of services and exceptional patient care.
CMC operates from two locations, just 1.3 miles apart, and is the largest hospital in the region. It is a world-class facility with more than 1,100 physicians and providers specialising in various medical fields. CMC is the only Level 1 trauma centre in the region and is approved for heart, kidney, pancreas, and liver transplants. It also serves as one of North Carolina's Academic Medical Centre Teaching Hospitals, providing residency training for physicians in multiple specialties.
In terms of rankings, Atrium Health Carolinas Medical Center is nationally recognised in one adult specialty and ten pediatric specialties. It is rated as high-performing in three adult specialties and twenty procedures and conditions. US News and World Report consistently rank CMC highly, and it has been named the No. 1 Best Hospital in the Charlotte region. The hospital's commitment to excellence is further demonstrated by its Magnet recognition by the American Nurses Credentialing Center's Magnet Recognition Program®.
Atrium Health Carolinas Medical Center is also known for its research collaborations. Researchers at the F.H. Sammy Ross Trauma Center are working with the University of Pittsburgh on the Prehospital Analgesia Intervention (PAIN) Trial. This research aims to optimise trauma patient care by evaluating the effects of administering fentanyl or low-dose ketamine to patients in mild shock. Additionally, CMC is home to the Levine Cancer Institute's academic and research headquarters and is affiliated with the Wake Forest University School of Medicine.
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Mission Hospital, Asheville, No. 1 in NC
Mission Hospital in Asheville, North Carolina, is a highly-regarded medical facility with a rich history dating back to 1885. It has earned a reputation as one of the best hospitals in the state, known for its excellence in patient care and innovative surgical procedures.
The hospital's origins can be traced to a group of women called "The Little Flower Mission," who recognised the need for a hospital that would serve anyone in need, regardless of their financial situation. Their dedication laid the foundation for what would become a leading healthcare institution in the region.
Today, Mission Hospital is a full-service, general medical and surgical facility serving Asheville, Buncombe County, and much of Western North Carolina. It offers cutting-edge services across multiple locations, including the main hospital, Mission Hospital-St. Joseph's campus, and Mission Children's Hospital, with over 50 medical specialties. The hospital's commitment to nursing excellence has been recognised, earning the prestigious Magnet Designation from the American Nurses Credentialing Center.
Mission Hospital is also an innovative surgical leader, offering advanced procedures such as laparoscopic and robotic minimally invasive techniques. With 11 robotic consoles, their surgical team operates one of the busiest robotic programs in the Carolinas. The hospital's approach combines leading-edge methods with a compassionate, patient-focused mindset, ensuring shorter stays and faster recovery for patients.
In addition to its medical expertise, Mission Hospital has demonstrated resilience in the face of natural disasters. During Hurricane Helene, the hospital's ER treated over 500 patients in the initial hours, showcasing its ability to provide critical care during emergencies. This hospital's dedication to its community, combined with its comprehensive range of services and surgical expertise, solidifies its reputation as one of the leading hospitals in North Carolina.
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Frequently asked questions
Duke University Hospital in Durham is highlighted as one of the best hospitals in the nation by U.S. News & World Report. It is nationally ranked in 11 adult and nine pediatric specialties.
Other top hospitals in North Carolina include:
- Moses H. Cone Memorial Hospital, Greensboro, NC
- Novant Health Presbyterian Medical Center, Charlotte, NC
- Atrium Health’s flagship hospital in Dilworth
- UNC Rex Hospital
- ECU Health Medical Center
- FirstHealth Moore Regional Hospital
- Mission Hospital-Asheville
Hospitals in North Carolina are ranked based on several factors, including:
- Patient satisfaction
- Infection rates
- Readmission statistics
- Mortality rates for common medical procedures
- Safety scores
- Recognition awards
- National performance ratings
WakeMed Raleigh is the largest hospital in Wake County by the number of beds. It delivered nearly 10,000 births during its 2024 fiscal year.























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